Chitin and Chitosan for Regenerative Medicine by Pradip Kumar Dutta

By Pradip Kumar Dutta

The e-book is a superb reference for scientists, researchers and scholars operating within the box of parts of biopolymeric biomaterials, biomedical engineering, therapeutics, tissue engineering and regenerative medication. The publication is split into elements: half i'll specialise in the tissue engineering and half II specializes in therapeutics, functionalization and computer-aided options. The e-book involves thirteen chapters contributed by means of 20 foreign participants who're prime specialists within the box of biopolymers and its purposes. it's going to specialise in the developments of chitin and chitosan in regenerative drugs.

Regenerative medication in tissue engineering is the method of exchanging or regenerating human cells, tissues, or organs to revive or determine common functionality. it really is an extremely revolutionary box of drugs which can, within the close to destiny, aid with the lack of life-saving organs to be had via donation for transplantation vis-a-vis regenerative medication specializes in therapeutics, functionalization and computer-aided techniques.

It additionally covers actual and chemical features of chitin and chitosan, structural differences for biomedical purposes, chitosan established scaffolds and biomodelling in tissue engineering, nanomedicines and healing functions. With the huge variety of functions, the realm is anticipating biopolymers to function the foundation for regenerative drugs and biomedical applications.

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Additional info for Chitin and Chitosan for Regenerative Medicine

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In vitro and in vivo studies demonstrated the biocompatibility of the hydrogel and its ability to support vascularization and regeneration of adipose tissue in rats [143]. Additionally, collagen–chitosan hydrogels have shown Chitosan Hydrogels for Regenerative Engineering 25 to stimulate signaling molecules such as nitric oxide for tissue healing when used as a delivery system for ADSCs [144]. In addition to preformed scaffolds, injectable biodegradable hydrogels are also been investigated for adipose tissue regeneration.

Injectable, thermosensitive poly(organophosphazene) hydrogel loaded with galactosylated chitosan-g-PEI/ DNA complexes showed excellent transfection in vitro in HepG2 and in vivo in BALB/c mice. Results indicated that the galactosylated hydrogel complex was less toxic and was able to accumulate in the liver over time, indicating better hepatocyte targeting [151]. 8 Intervertebral Disk Regenerative Engineering Intervertebral disks (IVDs) consist of two regions—an inner soft region called nucleus pulposus (NP) and an outer region called annulus fibrosus that surrounds the nucleus region [152].

Lee YH, Chang JJ, Yang MC, Chien CT, Lai WF (2012) Acceleration of wound healing in diabetic rats by layered hydrogel dressing. Han T, Nwe N, Furuike T, Tokura S, Tamura H (2012) Methods of N-acetylated chitosan scaffolds and its in vitro biodegradation by lysozyme. J. Verheul RJ, Amidi M, van Steenbergen MJ, van Riet E, Jiskoot W, Hennink WE (2009) Influence of the degree of acetylation on the enzymatic degradation and in vitro biological properties of trimethylated chitosans. Chung YC, Chen CY (2008) Antibacterial characteristics and activity of acid-soluble chitosan.

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