Biopolymers by Magdy M Elnashar

By Magdy M Elnashar

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Tissue engineering is a recent, advanced technology to develop living tissue substitutes and replace diseased or damaged tissues and organs in the human body. Tissue engineering applies the development of polymeric scaffolds, that, among other characteristics, are biodegradable and biocompatible. These scaffolds may be used simultaneously as a carrier matrix for bioactive agents and as a support for primary undifferentiated cells in vitro. The three-dimensional (3D) framework of a scaffold must be able to promote adherence, proliferation and differentiation of cells, which ultimately are guided to form the desired tissues.

Various cells in the dermis and epidermis are involved in these responses and they secrete various cytokines, particularly pro-inflammatory cytokines that cause skin irritation in vitro. Cytokines are low molecular weight glycoproteins that are produced by immune and non-immune cells. They are pleiotropic and interact with various receptors expressed on the surface of target cells. The binding of cytokines to cell surface receptors triggers intracellular signaling, protein synthesis and the production of other cytokines.

5] Elnashar, M. M. (2010). In Biopolymers: Bioapplications of chitosan. Novapublisher, Accepted and in press. [6] Fisher, J. Arnold JPR. (1999). In chemistry for biologists. BIOSS Scientific Publishers Ltd. Oxford. pp 64-95, 198-207. [7] Voet, D. & Voet, J. G. (1995). Biochemistry. New York: John Wiley & Sons. pp 29-104 & 331-370. [8] Hartmeier, W. (1988). Immobilized biocatalysts. Spring-Verlag, New York. pp. 4-90. [9] Boyer, R. F. (1993). In modern experimental biochemistry (2nd edition). , pp.

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