By Jonathan Black
Basic CONSIDERATIONSBiocompatibility: Definitions and concerns advent organic functionality Consensus Definitions dialogue The self-discipline of Biomaterials Afterword: Paradigmatic Shift creation to the organic atmosphere basic concerns comparability of exterior and inner ConditionsProblems in Definition of the organic EnvironmentElements of the organic surroundings Implant existence History Preimplantation dealing with results fabric reaction: functionality ANDDEGRADATION OF MATERIALSIN VIVOSwelling and Leaching creation Fick's legislation of DiffusionAbsorption Examples of Undesi. Read more...
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Additional info for Biological Performance of Materials : Fundamentals of Biocompatibility, Fourth Edition
6 43 Leaching The simplest case that results in leaching is that of removal of diffusing material from the surface at a constant rate. This is approximately the case of elution by moving blood; it is closely parallel to the in vitro situation of evaporation from a surface. 3. In most real situations, an additional condition is present. If the fluid medium is in motion but not fully stirred (as shown), some rate of transfer must be assumed. The simplest case is to take this rate as proportional to the surface concentration at any moment.
S. , Lippincott, Williams & Wilkins, Philadelphia, 2000. , Biomedical Engineering Principles, Marcel Dekker, New York, 1976. , McGraw–Hill, New York, 2003. L. and Kereluk, K. ), Sterilization of Medical Products, Johnson & Johnson, New Brunswick, NJ, 1977. M. , Advances in the processing, sterilization, and crosslinking of ultrahigh molecular weight polyethylene for total joint arthroplasty, Biomaterials, 20, 1659, 1999. LeVeau, B. B. Saunders, Philadelphia, 1977. , Gibson, C. , Sterilization of implantable devices, Clin.
It is difficult to obtain engineering properties of biological materials for use in design processes. With a group of contributors, Black and Hastings (1998) took a major step by attempting to collate reliable properties of normal human tissues and fluids. However, effects of age and disease processes on engineering properties of tissues are still not well reported. Reference should be made to contemporary literature or individual experimental studies may need to be undertaken to obtain design data for specific applications.